Nervous System Regulation
What is Vagus Nerve Stimulation (VNS)?
The Vagus Nerve is a continuous communication pathway between the body and brain controlling respiratory rhythm, cardiovascular activity, and gastrointestinal function. The vagus nerve is central to autonomic regulation and stress-related physiology, including neuroimmune responses.
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Vagus nerve stimulation (VNS) applies controlled electrical signals to balance vagal pathways. Vagus nerve stimulation is a credible and growing area within bioelectronic medicine—one that continues to be shaped by device engineering, research methodology, and careful interpretation of evidence.
Non-invasive cervical VNS (nVNS) devices have been medically evaluated and approved for treatment of migraines and cluster headaches. Emerging research highlights using nVNS for sleep and stress regulation as well as anxiety-related symptoms. This indicates the autonomic output of the vagus nerve contributes to physiological resilience and recovery-related processes.​
The Specific non-invasive vagus nerve stimulator that we use is Pulsetto
At Therapy323, we buy direct from Pulsetto and pass the savings on to YOU!
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We offer an equipment rental program to our patients, allowing you to try before you buy. Take the product home for 1 week, 2 weeks, or even a full month and try it for yourself. We will demonstrate equipment usage before your rental so you know what you're doing.
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If you like what you try, we can sell you the product at a discount saving you about 10%, AND you won't have to pay shipping!
Pulsetto has conducted their own research on their products, specifically demonstrating the benefits of bilateral versus unilateral cervical stimulation.
Clinical Studies of Non-Invasive Cervical VNS
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Study evaluating the safety and effectiveness of the Pulsetto device in reducing depressive symptoms, anxiety, and sleep disturbances in 40 participants over a 4-week period:
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Depressive symptoms dropped by 56%
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Anxiety reduced by 45%
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Sleep quality improved by 41%
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Study investigating cortisol (stress) levels measured hair samples collected before and after the 4-week Pulsetto intervention.
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70.3% of participants experienced a reduction in cortisol levels.
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Among them, cortisol levels dropped by 31% with one-sided stimulation, and by 47.5% with two-sided stimulation, showing a stronger and statistically significant effect.
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Men showed a 41.2% reduction in cortisol and women a 36.7% reduction.
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Study investigating cortisone levels (different biomarker of chronic stress), were also measured from hair samples collected before and after the 4-week Pulsetto intervention.
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62.2% of participants experienced a reduction in cortisone levels. The average cortisone level decreased from 70.56 to 43.75, representing a mean reduction of 26.81 units.
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Among participants who showed a cortisone decrease, levels dropped on average by 51.7%.
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Two-sided stimulation produced a significantly greater effect than one-sided. Participants receiving bilateral stimulation showed a 63.2% reduction, while those with unilateral stimulation experienced a 36.2% reduction.
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Other objective research on non-invasive vagus nerve stimulation shows it is very promising as a physical therapy modality.
2025
Dr. Christian Riediger, Dr. Mark Ferl, Dr. Maria Schönrogge and Dr. Agnieszka Halm-Pozniak
2024
Chaoran Wang, Bangqi Wu, Ruolan Lin, Yupei Cheng, Jingjie Huang, Yuyan Chen, Jing Bai
2023
Alexandra Evancho, William J. Tyler, Keith McGregor