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Parkinson's Disease

What is Parkinson's Disease?

Parkinson's Disease is a neurodegenerative disorder that affects predominately the dopamine-producing neurons in the brain. The progression of symptoms is often a bit different from person to person due to the diversity of the disease.

 

Symptoms Include

  • Tremor, mainly at rest and described as pill rolling tremor in hands; other forms of tremor are possible

  • Slowness and paucity of movement (called bradykinesia and hypokinesia)

  • Limb stiffness (rigidity)

  • Gait and balance problems (postural instability)

  • Non-motor-related symptoms: depression, anxiety, apathy, hallucinations, constipation, orthostatic hypotension, sleep disorders, loss of sense of smell, and a variety of cognitive impairments.

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What is Parkinson’s disease?

Parkinson’s is a progressive neurological condition that affects movement, caused by a loss of dopamine-producing brain cells.

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What are the early signs of Parkinson’s?

  • Small tremor (often in one hand)

  • Reduced arm swing when walking

  • Changes in handwriting (smaller, cramped)

  • Loss of smell

  • Sleep disturbances (acting out dreams)

  • Subtle stiffness or slowness

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Is Parkinson’s hereditary?

Most cases are not directly inherited, but genetics can increase risk in some people.

 

How is Parkinson’s diagnosed?

There’s no single test. Diagnosis is based on:

  • Medical history

  • Neurological exam

  • Response to Parkinson’s medications

  • Sometimes imaging to rule out other conditions

 

Is there a cure?

No cure currently exists, but treatments, such as medications and therapies, can significantly manage symptoms and improve quality of life.

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How does Parkinson’s progress?

It progresses gradually. Symptoms worsen over time, but the rate varies widely between individuals.

 

Can exercise help?

Yes—exercise is one of the most important treatments. It can help improve mobility and balance, reduce stiffness, and help with mood and fatigue.
 

Does Parkinson’s only affect movement?

No. It also causes non-motor symptoms, such as:

  • Chronic pain

  • Fatigue

  • Depression/anxiety

  • Sleep issues

  • Cognitive changes
     

Why do people with Parkinson’s experience pain?

Pain can come from:

  • Muscle stiffness and rigidity

  • Abnormal movement patterns

  • Nervous system changes affecting pain processing
     

What is “freezing” in Parkinson’s?

A temporary inability to move, often when starting to walk or turning—people feel like their feet are “stuck.”

 

Can Parkinson’s cause fatigue?

Yes, and it can be severe. It’s not just tiredness—it’s often described as a whole-body exhaustion.

 

Does Parkinson’s affect thinking or memory?

It can, especially in later stages. Some people develop mild cognitive impairment or dementia.

 

Is Parkinson’s life-threatening?

Not directly, but complications (like falls or swallowing issues) can impact life expectancy.

 

Can younger people get Parkinson’s?

Yes—this is called young-onset Parkinson’s, though it’s less common.

 

What helps most with quality of life for Parkinson's?

  • Consistent exercise

  • Physical/occupational therapy

  • Medication optimization

  • Social support and mental health care

2024

Beatriz Alves, Pedro R Mota, Daniela Sineiro, Ricardo Carmo, Pedro Santos, Patrícia Macedo, João Casaca Carreira, Rui Neves Madeira, Sofia Balula Dias, Carla Mendes Pereira

2022

Jacqueline A Osborne, Rachel Botkin, Cristina Colon-Semenza, Tamara R DeAngelis, Oscar G Gallardo, Heidi Kosakowski, Justin Martello, Sujata Pradhan, Miriam Rafferty, Janet L Readinger, Abigail L Whitt, Terry D Ellis

2021

Terry D. Ellis, Cristina Colón-Semenza, Tamara R. DeAngelis, Cathi A. Thomas, Marie, Hélène Saint Hilaire, Gammon M. Earhart, Leland E. Dibble

2018

Divya M Radhakrishnan, Vinay Goyal

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